HPMC E5

HPMC E5 (Hydroxyl propyl methyl cellulose) is a nonionic cellulose ether. It is used for pharmaceuticals products as it has viscosity of around 4-6 mPa·s, which is low in nature. It works as a thickener as both in water and other chemical directly as well. It is a clear fine white powder with grease resistance, binder, lubricants, stabilizers and water retention aid.

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Description

From building strength to ensuring purity Sakshi chem Sciences Pvt Ltd., proudly enters the pharmaceutical area with our new pharma grade HPMC.

Following earning trust on detergent and establishing our quality in building we now extend the same commitment to the pharmaceutical.

HPMC E5 is white, water soluble powder with low viscosity, HPMC E5 is extensively applied on pharmaceutical industry as a a film former, binder, suspending agent, and in other Oral & topical formulations

It is best suited for tablet coating, film forming, and as a binder in a wet granulation. (to form granules)

HPMC E5 Properties:

  • It is mixed directly with water to form free flowing powder.
  • It makes smooth, thin, uniform films on tablet as it is versatile in film forming creation.
  • To make it suitable for adverse range, this polymer can be used with hydrophilic and hydrophobic drugs too.
  • HPMC E5 offers excellent adhesion properties.

Key benefits:

  • Thickening
  • Fast dissolving
  • Film forming
  • Nontoxic & bio compatible
  • Water retention
  • It is vegan as alternative to gelatin (animal based product).
  • low flowability, simple in handling while preparing solutions
  • stable over broad pH range
  • Suitable for fast release tablets
  • Produces shiny, protective and hard films.

Technical Specifications

State/Form Powder
Color White
Viscosity (mPa.s) 5
pH 4.0-8.0
Packaging Type Bucket / Paper Tube Barrel
Packaging Size 25 Kg

Applications: HPMC E5

1) Pharmaceuticals: As binder in tablet, thickener & film former, coating – produce smooth uniform film on tablets. also in ophthalmic application for eye drops, Oral liquid forms
2) Food Industry: In food processing as a thickener emulsifier, and stabilizer
3) Personal Care Products: Creams, lotions, shampoos, gel etc.
4) Coatings & Inks: Thickener

How It is Used:

Slowly add HPMC into water while stirring to avoid lump formation. Complete dissolving before mixing with other material gives better performance.

  • For tablets: It should be 1% – 5%
  • For plant capsules, film forming gel, stabilizer ointment emulsifier, solid dispersant: It should be 2% -10%

How to Store:

  • It should be place in dry & cool place
  • Avoid direct contact into sunlight as it may reduce quality
  • It should sealed packed after every use.

Additional information

Weight 25 kg
Dimensions 70 × 50 × 15 cm
What is HPMC E5?

HPMC E5 is defined as hydroxyl ethyl cellulose of generalized grade E5. It has low viscosity of around 5 mPa·s. It is specially used for pharmaceuticals uses like eye drops, tablet binder & coatings for speedy dissolving.

What does “E5” mean in HPMC?

E5 is grade which comes under E series. As it has viscosity of 5 mPa·s low in nature.

What are the common HPMC E5 pharmaceutical applications?

Tablet Coating, Capsule, Controlled Release, Disintegrant, etc.

What is HPMC E5 used for?

HPMC E5 is widely used in pharmaceuticals products.

Is HPMC E5 safe for human consumption?

Yes, it’s totally safe for skin and eyes as it is nontoxic biodegradable and non-Irritating. Also for food it is safe as approved by WHO as emulsifier stabilizer.

Can HPMC E5 be used in ophthalmic formulations?

Yes, HPMC E5 can be used as ophthalmic formulations, mostly for eye drops as it requires semisolid and liquid formed.

What is the recommended storage condition?

Storage should be in cool and dry place away from sunlight.

What is the solubility profile?

HPMC E5 is most effective for drugs that are poorly water-soluble as it increases solubility.

Does HPMC E5 affect drug bioavailability?

As HPMC E5 is mixed with the formulation, this formulators can improve the drug’s solubility and bioavailability, leading to better therapeutic outcomes for patients

What are the quality standards of pharmaceutical-grade HPMC E5?

Pharmaceutical products that require low viscosity in a range of E5 to control moisture content, to reflect impurity content, and to ensure that microbial(as bacteria, viruses, chemicals or parasites) contamination are allowed to be used in the pharmaceutical field.